Brenda Vaccaro Martin Fried, Articles X

7b(i) (ii), (iii), (iv), (vi), (ix), (x)). We investigated neuronal loss in both pericontusional areas and brain regions in the ipsilateral and contralateral hemispheres distant from the lesion. It gives me a The sample sizes (n) are indicated in the figure legends. Xenon treatment enhances early microglial proliferation. 3b) in the left motor cortex showed significant (p<0.05) loss in the TBI control group compared to the sham group in the TBI control group in layers 2 & 3, and layer 5, that was prevented in layer 5 and reduced in layers 2 &3 in the xenon-treated TBI group (Fig. frequent fatigue or burn-out syndrome. in my youth in Romania, on professional level. The scale bar is 1000m. The CatWalk-XT automated gait analysis system (Noldus Information Technology, Wageningen, the Netherlands) was used to measure locomotor function and gait parameters. Death Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP. As the null statistics for the KW test are known not to follow a chi-squared distribution for small numbers especially in the region of the 0.95 and 0.99 quantile, results from the KW test were compared to the exact results for a KW test using a program written in Mathematica (Mathematica 11.3.0.0, Wolfram Research Inc.) [39]. We chose to examine cortical and subcortical brain regions (Fig. We used a translationally relevant concentration of xenon that would allow supplementary oxygen to be given if required. In the left and right CA1 and DG hippocampal subregions, and in the left CA3 subregion there was a significant (p<0.05) increase in median number of microglia in the xenon-treated group compared to the sham group (Fig. Figure7a shows representative GFAP-positive astrocytes in the right hippocampal CA1 region from sham, TBI control and TBI xenon groups. There was a significant reduction in locomotor speed in the TBI control group at 24h, while this reduction was absent in the TBI xenon group. Article In order to avoid any confounding effects from the anesthesia and analgesia, we were careful to ensure that the sham group received exactly the same drugs. 2017;8:354. Anesthesiology. 3b(i)). However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving Xenon Xe 133 gas.