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Suboptimal response to GnRH-agonist trigger during oocyte cryopreservation: a case series. Letrozole is in the class of medicines Progesterone Letrozole competitively binds to the heme group of the cytochrome P450 subunit of aromatase, blocking the conversion of androstenedione and testosterone to oestrone and oestradiol, leading to an increase in androgen and a decrease in oestrogen levels (14). Patients in the GnRH-ant protocol received daily intramuscular injections of rFSH (125300 IU) from the first day of stimulation to the day of human chorionic gonadotropin (hCG) administration. Your post will be hidden and deleted by moderators. Figure3 Relationship between progesterone levels and the number of retrieved oocytes in GnRH-a and LE GnRH-ant groups. Pritts EA. Propensity score matching (PSM) was performed to balance the factors related to progesterone levels on trigger day. Patients in the LE GnRH-a group presented higher progesterone levels (1.22 0.95 ng/mL vs 0.86 0.60 ng/mL, P < 0.001), with higher proportion of patients with a progesterone level > 1.5 ng/ml (24.81% vs 7.52%, P < 0.001); higher P/E2 ratio (0.75 0.58 vs 0.43 0.60, P < 0.001), with higher proportion of patients with a P/E2 ratio > 0.55 (52.63% vs 17.67%, P < 0.001); higher POI (132.47 112.07 pg/mL vs 100.84 93.87 pg/mL, P < 0.001), and lower oestradiol levels on trigger day (2,259.90 1,779.14 pg/mL vs 2,773.54 1,830.26 pg/mL, P < 0.001) than those in the GnRH-ant group. We usually take this blood sample on day 21 of A blood test for progesterone a hormone produced after ovulation can also document that you're ovulating. If your progesterone levels do not rise, you are probably not ovulating. I was on a Letrozole cycle (having previously had progesterone levels <1 everytime I checked). First, LE is used to prepare the endometrium in the frozen embryo transfer (FET) cycle, and no negative effect on endometrial receptivity has yet been reported (58). Congratulations! Females who have low progesterone levels may have irregular periods and struggle to get pregnant. Short-Term Androgen Priming by Use of Aromatase Inhibitor and hCG Before Controlled Ovarian Stimulation for IVF. Again, could be totally wrong. The Value of Serum Progesterone Level on Day of Human Chorionic Gonadotrophin Administration/Metaphase II Oocyte Ratio in Predicting IVF/ICSI Outcome in Patients With Normal Ovarian Reserve. Web3. 2015 Sep;30(9):2184-9. doi: 10.1093/humrep/dev155.